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The New York Knicks and the Indiana Pacers link up in Game 4 of the 2025 NBA Eastern Conference finals on Tuesday night. The Pacers jumped out to a 2-0 series lead after taking both games at MSG. With their backs against the wall, the Knicks rallied from a 20-point deficit and beat Indiana 106-100 in Game 3 as the 100 points was the fewest Indiana scored since Feb. 4. Aaron Nesmith (ankle) is listed as available for Indiana after originally being questionable.

Tipoff is at 8 p.m. ET from Gainbridge Fieldhouse in Indianapolis. Indiana is a 3-point favorite in the latest Pacers vs. Knicks odds from DraftKings Sportsbook, while the over/under for total points scored is 219.5, a 3-point decrease from opening at 222.5. Indiana is priced at -154 on the money line (risk $154 to win $100), while New York is listed at +129 (risk $100 to win $129). Before locking in any Knicks vs. Pacers picks, make sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the conference finals of the 2025 NBA playoffs on a sizzling 159-117 roll on all top-rated NBA picks, returning nearly $4,000. It is also 23-11 (68%) on top-rated NBA against-the-spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Knicks vs. Pacers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Knicks vs. Pacers:

Knicks vs. Pacers spread

Indiana -3 at DraftKings

Knicks vs. Pacers over/under

219.5 points

Knicks vs. Pacers money line

Indiana -154, New York +129

Knicks vs. Pacers picks

See picks at SportsLine

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Why the Knicks can cover

The Knicks have some momentum going into this contest after coming back from a 20-point hole in Game 3. The pressure is back on Indiana, and New York hopes to capitalize. The Knicks are 32-25-1 against the spread with one day of rest. This team was also 32-23-1 against the spread with equal rest.

Forward Karl-Anthony Towns carried this group when it mattered in Game 4. Towns finished with 24 points and 15 rebounds, while scoring a team-high 20 points in the fourth quarter. Guard Jalen Brunson is another reliable offensive outlet, scoring 23 points in Game 3. See which team to back at SportsLine.

Why the Pacers can cover

The Pacers are 19-13-2 against the spread after a loss, with a 9-4 mark against the spread in the playoffs. Guard Tyrese Haliburton is a quality playmaker who can also create his own shot. In the 2025 NBA playoffs, he leads the team in assists (9.4) with 18.5 points and 5.5 rebounds per game. In his last game, Haliburton had 20 points and seven dimes.

Center Myles Turner has the skillset to score from inside and outside. This postseason, he's logging 16.5 points, 5.5 rebounds and 2.3 blocks per game. He's scored at least 14 points and two blocks in two consecutive games. On Sunday, Turner finished with 19 points, four rebounds, three assists and two blocks. See which team to back at SportsLine. 

How to make Knicks vs. Pacers picks

SportsLine's model has simulated Knicks vs. Pacers and is leaning Over the total, projecting 220 combined points. The model also says one side of the spread hits in well over 50% of simulations You can head to SportsLine to see the model's NBA picks. 

So who wins Knicks vs. Pacers, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Knicks vs. Pacers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.