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The Detroit Pistons (41-32) host the Cleveland Cavaliers (59-14) in an Eastern Conference tilt on Friday. The Pistons have won four of their last five games, including two straight. On Tuesday, Detroit defeated the San Antonio Spurs 122-96. Meanwhile, Cleveland defeated the Spurs 124-116 last night. That was their third straight win. Cade Cunningham (calf) is out for the Pistons, while Max Strus (ankle) and Ty Jerome (knee) are out for Cleveland.

Tipoff is at 7 p.m. ET from the Little Caesars Arena in Detroit. Cleveland has won 12 straight games versus Detroit, including a 118-115 victory on Feb. 5. The Cavs are 6.5-point favorites in the latest Cavaliers vs. Pistons odds from SportsLine consensus, down from opening as 9.5-point favorites. The over/under for total points scored is 231.5. Before locking in any Cavaliers vs. Pistons picks, make sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 23 of the 2024-25 NBA season on a sizzling 153-113 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 20-10 (67%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Cavaliers vs. Pistons 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Cavaliers vs. Pistons:

  • Cavaliers vs. Pistons spread: Cleveland -6.5 at DraftKings Sportsbook
  • Cavaliers vs. Pistons over/under: 231.5 points
  • Cavaliers vs. Pistons money line: Cleveland -261, Detroit +211
  • CLE: The Cavs are 44-28-1 against the spread this season 
  • DET: The Pistons are 39-31-3 against the spread this season 
  • Cavaliers vs. Pistons picks: See picks at SportsLine
  • Cavaliers vs. Pistons streaming: FuboTV (Try for free)
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Why the Cavaliers can cover

Guard Donovan Mitchell is an athletic shot creator and ball handler for Cleveland. He leads the team in points (23.7) and steals (1.3) with 4.8 assists per game. Mitchell also shoots 36.7% from beyond the arc. On March 19 against the Kings, Mitchell finished with 26 points, five rebounds and four assists.

Guard Darius Garland has great vision as a playmaker and a soft touch as a scorer. Garland logs 20.8 points, 6.7 assists and makes 40% of his 3-pointers. He's scored at least 20 points in five of his last 10 games. In Tuesday's win over the Trail Blazers, Garland had 27 points, five rebounds and eight assists. See which team to back at SportsLine.

Why the Pistons can cover

Center Jalen Duren is an active force in the frontcourt. Duren averages 11.7 points, 10.2 rebounds and 1.1 blocks per game. He's also second in the NBA in field-goal percentage (69.9%). In the March 23 win over the Pelicans, Duren had 22 points and 12 boards. The Memphis product has 35 double-doubles this season.                          

Guard Malik Beasley is a two-way sharpshooter for Detroit. Beasley averages 16.2 points, 2.7 rebounds and makes 42% from 3-point downtown. The Florida State product has six straight games with 10-plus points. On March 21 against the Mavericks, Beasley racked up 16 points, two assists, and went 5-of-11 from downtown. See which team to back at SportsLine. 

How to make Cavaliers vs. Pistons picks

SportsLine's model has simulated Cavaliers vs. Pistons and is leaning Under the total, projecting 231 combined points. The model also says one side of the spread hits in well over 50% of simulations. You can head to SportsLine to see the model's NBA picks. 

So who wins Cavs vs. Pistons, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Cavs vs. Pistons spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out. 

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