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The Boston Red Sox will battle the Washington Nationals in an interleague matchup on Friday. Both teams are coming off interleague series wins. The Red Sox (43-45), who are fourth in the American League East, are 18-25 on the road this season. The Nationals (37-50), fifth in the National League East, are 18-25 on their home field in 2025.

First pitch for the Fourth of July clash from Nationals Park in Washington, D.C., is set for 11:05 a.m. ET. The Nationals have won four of the last six meetings with the Red Sox. Boston is a -113 favorite on the money line (risk $113 to win $100) in the latest Red Sox vs. Nationals odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8.5. Before making any Red Sox vs. Nationals picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 15 of the 2025 MLB season on a profitable 39-30 run on top-rated MLB sides picks. It has excelled making home run prop picks this season, returning more than 24 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.

Now, the model has set its sights on Red Sox vs. Nationals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Red Sox vs. Nationals, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Red Sox vs. Nationals money line

Boston -113, Washington -106 at DraftKings Sportsbook    

Red Sox vs. Nationals over/under

8.5 runs

Red Sox vs. Nationals run line 

Boston -1.5 (+144)

Red Sox vs. Nationals picks

See picks at SportsLine

Red Sox vs. Nationals streaming 

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Why the Red Sox can win

Right-hander Lucas Giolito (4-1, 3.99 ERA) is expected to get the start for Boston. In 11 starts this season, he has pitched 58.2 innings, allowing 26 earned runs, 60 hits and 18 walks with 51 strikeouts. He is coming off a 15-1 win over the Toronto Blue Jays on Saturday. In that outing, he pitched seven innings, allowing six hits, one run -- none earned -- with one walk and five strikeouts.

Among Boston's top hitters is right fielder Wilyer Abreu. In 76 games, he is hitting .261 with 10 doubles, 17 homers, 48 RBI and five stolen bases. He has hits in five of the last six games, including a 2-for-5 performance with two homers and five RBI in a 13-6 win over the Cincinnati Reds on Monday. He was 3-for-7 with a homer and three RBI in the doubleheader split with the Reds on Wednesday. See which team to back at SportsLine.

Why the Nationals can win

Washington is expected to send right-hander Michael Soroka (3-5, 4.70 ERA) to the mound. In 11 starts this season, he has logged 59.1 innings, allowing 46 hits, 31 earned runs, 10 homers and 15 walks with 64 strikeouts. He received a no-decision in his last outing, an 8-2 loss to the Los Angeles Angels on Saturday. In that game, he pitched six innings, allowing two hits, one earned run and one walk, while striking out five.

Among the Nationals' best offensive weapons is left fielder James Wood. In 87 games, he is batting .294 with 19 doubles, 23 homers and 67 RBI. He has a six-game hitting streak and has hits in eight of his last 10 games. He was 5-for-5 with a homer, two RBI and three runs scored in Thursday's win over the Detroit Tigers. In Saturday's loss to the Angels, he was 2-for-4. He was 3-for-5 with a homer and four RBI in a 10-6 win over the San Diego Padres on June 23. See which team to back at SportsLine

How to make Red Sox vs. Nationals picks

SportsLine's model is leaning Over on the total, projecting 9.7 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model's MLB picks

So who wins Red Sox vs. Nationals, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.