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The Detroit Tigers will look to turn their road fortunes around when they battle the Houston Astros in the third and final game of their series on Wednesday. Houston earned an 8-5 win on Monday, and a come-from behind 6-4 victory on Tuesday. The Tigers (18-12), who lead the American League Central, are just 5-9 on the road in 2025. The Astros (16-13), who have a plus-16 run differential, are 11-6 on their home field this season.

First pitch from Daikin Park in Houston is set for 2:10 p.m. ET. The Astros have won eight of the last 12 meetings against the Tigers. Houston is a -125 favorite on the money line (risk $125 to win $100) in the latest Astros vs. Tigers odds from Fanduel Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8.5. Before making any Tigers vs. Astros picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 6 of the 2025 MLB season on a 17-11 run on top-rated MLB betting picks (+276). Anybody following at sportsbooks and on betting apps could have seen strong returns.  

Now, the model has set its sights on Tigers vs. Astros and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Astros vs. Tigers:

  • Tigers vs. Astros money line: Detroit +105, Houston -125 at FanDuel Sportsbook
  • Tigers vs. Astros over/under: 8.5 runs  
  • Tigers vs. Astros run line: Houston -1.5 (+163)
  • DET: The under is 4-1-1 in the Tigers' last six games  
  • HOU: The under is 7-3 in the Astros' last 10 games     
  • Tigers vs. Astros picks: See picks at SportsLine
  • Tigers vs. Astros streaming: FuboTV (Try for free)

Why the Astros can cover

Houston is expected to either call up A.J. Blubaugh for a spot start. In four starts at AAA Sugar Land of the Pacific Coast League, he is 2-2 with a 3.86 ERA. In 12 starts at Sugar Land in 2024, he was 12-4 with a 3.83 ERA. In four minor league seasons, he has gone 22-10 with a 4.02 ERA in 65 games, including 44 starts.

Left fielder Jose Altuve is among Houston's top hitters. In 28 games this season, he is batting .272 with two doubles, four homers and 12 RBI. He had two hits, one homer and three RBI in Monday's series opener. He has always hit Tigers pitching well. In 43 career games against Detroit, he is batting .306 with seven doubles, one triple, eight homers and 21 RBI. See which team to back at SportsLine.

Why the Tigers can cover

Detroit is expected to counter with right-hander Jackson Jobe (2-0, 2.70 ERA). In his last outing, a 7-3 win over the Kansas City Royals, he picked up the victory, pitching five innings and allowing five hits, one earned run and two walks, while striking out five. He also earned a win in a 4-0 triumph at Minnesota on April 12. In that game, he went six innings, allowing just two hits and one walk, while striking out two.

Second baseman Gleyber Torres is coming off a solid performance in Tuesday's loss to the Astros. He went 3-for-5 with a homer and three RBI. In 18 games this season, he is batting .292 with two doubles, three homers and 14 RBI. In 40 career games against Houston, he is hitting .257 with five doubles, seven homers and 20 RBI. See which team to back at SportsLine. 

How to make Tigers vs. Astros picks

SportsLine's model is leaning Over on the total, projecting 9.4 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model's MLB picks. 

So who wins Astros vs. Tigers, and which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.