| Starling Marte | Knee | 03-12-2025Questionable for start of season |
| Sean Manaea | Oblique | 04-14-2025Expected to be out until at least Apr 15 |
| Frankie Montas | Lat | 05-14-2025Expected to be out until at least May 15 |
| Drew Smith | Elbow | 08-31-2025Expected to be out until at least Sep 1 |
| Nick Madrigal | Shoulder | 01-31-2026Expected to be out until at least Feb 1, 2026 |
| Ronny Mauricio | Knee | 03-31-2025Expected to be out until at least Apr 1 |
| Francisco Alvarez | Hand | 04-24-2025Expected to be out until at least Apr 25 |
| Dedniel Nunez | Elbow | 03-26-2025Expected to be out until at least Mar 27 |
| Christian Scott | Elbow | 01-31-2026Expected to be out until at least Feb 1, 2026 |
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