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Now it's time to set your Week 4 Fantasy Football lineups.

Jamey Eisenberg has all the Start 'Em & Sit 'Em insight you'll need to make sound decisions at quarterback ahead of Week 4, right here. His Waiver Wire column can also direct you to the best options that may be available in your leagues. And don't forget to check out Heath Cummings' quarterback preview for more help with matchup notes, Week 4 numbers to know and more. Plus check out Heath's Week 4 projections over at SportsLine.

QBs to Start
Projections powered by Sportsline
DAL Dallas • #4
Age: 31 • Experience: 9 yrs.
Weekly Breakdown
MATCHUP
@ NYG DAL -5.5 O/U 45
OPP VS QB
4th
PROJ PTS
20.7
QB RNK
9th
YTD Stats
PAYDS
851
RUYDS
22
TD
5
INT
2
FPTS/G
20.7
Prescott just had his best game of the season in Week 3 against Baltimore with 33.9 Fantasy points, and hopefully that's a sign of things to come. He should stay hot in Week 4 at the Giants, and he has a great history in this NFC East rivalry. In his past five games against the Giants, Prescott is averaging 265.4 passing yards with 11 total touchdowns and four interceptions. He threw for 404 yards, four touchdowns, one interception, and a rushing touchdown, the last time he played the Giants in 2023.
TB Tampa Bay • #6
Age: 29 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
vs PHI PHI -2.5 O/U 45
OPP VS QB
14th
PROJ PTS
18.7
QB RNK
10th
YTD Stats
PAYDS
637
RUYDS
55
TD
7
INT
2
FPTS/G
23
Mayfield suffered his first bad game of the season in Week 3 against Denver when he scored just 10.5 Fantasy points, but he should bounce back in Week 4 against the Eagles. Jordan Love and Kirk Cousins both had at least 241 passing yards and two touchdowns against Philadelphia, and Mayfield destroyed the Eagles in the playoffs last season with 337 passing yards, three touchdowns and no interceptions, along with 16 rushing yards.
SEA Seattle • #7
Age: 34 • Experience: 12 yrs.
Weekly Breakdown
MATCHUP
@ DET DET -3.5 O/U 47
OPP VS QB
27th
PROJ PTS
18.8
QB RNK
12th
YTD Stats
PAYDS
787
RUYDS
36
TD
4
INT
3
FPTS/G
17.7
Smith has faced the Lions in each of the past two seasons in Detroit, and he's combined for 648 passing yards, four touchdowns and no interceptions, along with 69 rushing yards and a touchdown, in those two outings. I'm expecting another solid performance against the Lions in Week 4, and this should be Smith's best game to date since he's yet to score more than 19.9 Fantasy points. I'm trusting Smith as a low-end starter in all leagues.
MIN Minnesota • #14
Age: 27 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
@ GB GB -2.5 O/U 43.5
OPP VS QB
1st
PROJ PTS
16.5
QB RNK
11th
YTD Stats
PAYDS
657
RUYDS
35
TD
8
INT
2
FPTS/G
24.6
Darnold looks awesome right now in Kevin O'Connell's offense, and he's scored at least 23.9 Fantasy points in each of his past two games against the 49ers and Texans, with six passing touchdowns over that span. This week, he's taking on a Packers defense that has more interceptions (seven) than touchdowns allowed (five), but Green Bay is also ninth in passing yards allowed to quarterbacks with 742. I'm buying this hot start by Darnold, and he's worth using as a low-end starter in all leagues.
SF San Francisco • #13
Age: 24 • Experience: 3 yrs.
Weekly Breakdown
MATCHUP
vs NE SF -10.5 O/U 40.5
OPP VS QB
16th
PROJ PTS
18.9
QB RNK
12th
YTD Stats
PAYDS
842
RUYDS
64
TD
4
INT
1
FPTS/G
19.3
Purdy looks like he'll get some help this week with Deebo Samuel (calf) and George Kittle (hamstring) back at practice, but Purdy didn't need them in Week 3 at the Rams when he passed for 292 yards and three touchdowns, along with 41 rushing yards. Aaron Rodgers and Geno Smith combined for 608 passing yards and three touchdowns against the Patriots in the past two games, and Purdy should be considered a low-end starter this week. Hopefully, Brandon Aiyuk steps up with his first big game of the season, and we'll see what happens with Jauan Jennings now that everyone is healthy. But I expect Purdy to keep it rolling in this matchup with New England in Week 4.
Sleepers (Start/Sit)
Projections powered by Sportsline
PIT Pittsburgh • #2
Age: 25 • Experience: 4 yrs.
Fields went over 20 Fantasy points for the first time this season in Week 3 against the Chargers when he scored 20.4 points with 245 passing yards, one touchdown and one interception, along with 6 rushing yards and a touchdown. Hopefully this is the start of him producing at a higher level instead of just being a game manager, and this is a great matchup against the Colts. Caleb Williams just had 363 passing yards, two touchdowns and two interceptions against Indianapolis in Week 3. Malik Willis ran for 41 yards against the Colts in Week 2. And C.J. Stroud had 234 passing yards and two touchdowns against this defense in Week 1. Fields should be considered a low-end starter in all leagues.
CHI Chicago • #18
Age: 23 • Experience: Rookie
Kyler Murray and Brock Purdy have abused the Rams defense in the past two games for a combined 558 yards, six touchdowns and no interceptions, along with 15 carries for 100 yards. Williams just scored 21.3 Fantasy points in Week 3 at the Colts, and he should have the chance for another quality outing against the Rams at home. He's worth using as a low-end starter in all leagues.
CAR Carolina • #14
Age: 37 • Experience: 14 yrs.
Dalton looked amazing in his first start in place of Bryce Young in Week 3 at Las Vegas with 319 passing yards and three touchdowns. He should have a solid encore in Week 4 against the Bengals in a potential shootout with Joe Burrow. The projected score for this game is 48 points since neither defense is very good, and Cincinnati has allowed Patrick Mahomes and Jayden Daniels to each throw two touchdowns in the past two games. Dalton is more of a sleeper than a must-start quarterback, but I like him as a low-end No. 1 option in this matchup at home.
QBs to Sit
Projections powered by Sportsline
LAR L.A. Rams • #9
Age: 36 • Experience: 16 yrs.
Weekly Breakdown
MATCHUP
@ CHI CHI -3 O/U 41
OPP VS QB
13th
PROJ PTS
14.1
QB RNK
24th
YTD Stats
PAYDS
754
RUYDS
0
TD
2
INT
1
FPTS/G
12.7
Stafford pulled off a great comeback win in Week 3 against the 49ers, but he only scored 14.8 Fantasy points in the 27-24 victory. He's now scored 16.7 Fantasy points or less in three games this season, and it's tough to trust him in this matchup with the Bears when he's without Puka Nacua (knee) and Cooper Kupp (ankle). Chicago has yet to allow multiple touchdowns to any quarterback this year, including matchups with C.J. Stroud and Anthony Richardson over the past two games.
JAC Jacksonville • #16
Age: 25 • Experience: 4 yrs.
Weekly Breakdown
MATCHUP
@ HOU HOU -7 O/U 45
OPP VS QB
21st
PROJ PTS
17.9
QB RNK
NR
YTD Stats
PAYDS
560
RUYDS
56
TD
2
INT
1
FPTS/G
12.6
Lawrence continued his lackluster play in Week 3 at Buffalo with 11.4 Fantasy points, and he's now scored 13.3 Fantasy points or less in all three games this season. It will be tough to trust him in Week 4 at Houston even though the Texans just allowed four passing touchdowns against Sam Darnold in Week 3. In his last five games against Houston, Lawrence has passed for an average of 258.2 yards with three total touchdowns and five interceptions.
NYJ N.Y. Jets • #8
Age: 41 • Experience: 20 yrs.
Weekly Breakdown
MATCHUP
vs DEN NYJ -7.5 O/U 38.5
OPP VS QB
19th
PROJ PTS
19.7
QB RNK
18th
YTD Stats
PAYDS
624
RUYDS
18
TD
5
INT
1
FPTS/G
18.2
Rodgers played great against the Patriots in Week 3 with 25 Fantasy points, and he's now scored at least 19.1 Fantasy points in two games in a row. But Denver is actually a tough matchup, and the Broncos have yet to allow a quarterback to pass for 175 yards or multiple touchdown passes in a game this season against Geno Smith, Justin Fields and Baker Mayfield. I would only start Rodgers in Superflex and two-quarterback leagues in Week 4.
ATL Atlanta • #18
Age: 36 • Experience: 13 yrs.
Weekly Breakdown
MATCHUP
vs NO ATL -1.5 O/U 42.5
OPP VS QB
22nd
PROJ PTS
17.7
QB RNK
21st
YTD Stats
PAYDS
626
RUYDS
-2
TD
4
INT
3
FPTS/G
14.3
The Saints defense has been tough on opposing quarterbacks so far this season, and in the past two weeks, New Orleans has held Dak Prescott and Jalen Hurts to a combined one touchdown and three interceptions. Now, that duo passed for a combined 604 yards, but neither scored more than 15 Fantasy points. Cousins has topped 15 Fantasy points just once this year, and he's not worth trusting in this matchup in anything more than Superflex and two-quarterback leagues.
Bust Alert (Start/Sit)
Projections powered by Sportsline
IND Indianapolis • #5
Age: 22 • Experience: 2 yrs.
Weekly Breakdown
MATCHUP
vs PIT PIT -1.5 O/U 40
OPP VS QB
26th
PROJ PTS
18.1
QB RNK
13th
YTD Stats
PAYDS
583
RUYDS
117
TD
4
INT
6
FPTS/G
15.6
Richardson got off to a hot start in Week 1 against Houston with 30.1 Fantasy points, but the past two weeks against Green Bay and Chicago have been tough. He's combined for just 16.9 Fantasy points against the Packers and Bears, and he's struggled to throw the ball in those outings with a combined five interceptions. It won't get easier for him against the Steelers, who have allowed just two touchdowns with four interceptions against Kirk Cousins, Bo Nix and Justin Herbert. Hopefully, this is a game where Richardson gets his production on the ground, but he might not post a big stat line in this matchup. I would lower expectations for Richardson if you start him this week in one-quarterback leagues.

Who should you start and sit this week? And which surprising running back could lead you to victory? Visit SportsLine now to get Week 4 Fantasy projections for every position, plus see which RB comes out of nowhere to crack the top five, all from the model that has outperformed experts big-time